Early changes of brain perfusion after subarachnoid hemorrhage - the effect of sodium nitroprusside.
| Autor: | Kolar, M. |
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| Další autoři: |
Mareš, Jan, 1948-2021
Pachl, Jan, 1949-
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| Jazyk: | angličtina |
| Předmět: | |
| Druh dokumentu: | Non-fiction |
| ISSN: | 0862-8408 |
| Abstrakt: | Abstract: Causes of early hypoperfusion after subarachnoid hemorrhage (SAH) include intracranial hypertension as well as vasoconstriction. The aim of the study was to assess the effect of intrac erebroventricular (ICV) administration of sodium nitroprusside (SNP) on early hypoperfusion after SAH. Male Wistar rats (220-240 g) were used, SAH group received 250 μ l of fresh autologous arterial blood into the prechiasmatic cistern; sham-operated animal s received 250 μ l of isotonic solution. Therapeutic intervention: ICV administration of 10 μ g SNP; 5 μ l 5 % glucose (SNP vehicle) and untreated control. Brain perfusion and invasive blood pressure were monitored for 30 min during and after induction of SAH. Despite SNP caused increase of perfusion in sham -operated animals, no response was observed in half of SAH animals. The other half developed hypotension accompanied by brain hypoperfusion. There was no difference between brain perfusion in SNP-treated, glucose-treated and untreated SAH animals during the monitored period. We did not observe expected beneficia l effect of ICV administration of SNP after SAH. Moreover, half of the SNP-treated animals developed serious hypotension which led to brain hypoperfusion. This is the important finding showing that this is not the option for early management in patient aft er SAH. |
| Databáze: | Katalog Knihovny AV ČR |
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