New developments in septic acute kidney injury.

Autor:	Chvojka, J.
Další autoři:	Sýkora, R. Karvunidis, T. Raděj, Jaroslav Kroužecký, Aleš, 1971- Novák, I. Matějovič, Martin, 1969-
Jazyk:	angličtina
Předmět:	sepse patologická fyziologie proteomika sepsis pathological physiology proteomics články journal articles acute kidney injury
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: The kidney is a common “victim organ” of various insults in critically ill patients. Sepsis and septic shock are the dominant causes of acute kidney injury, accounting for nearly 50 % of episodes of acute renal failure. Despite our substantial progress in the understanding of mechanisms involved in septic acute kidney injury there is still a huge pool of questions preclusive of the development of effective ther apeutic strategies. This review briefly summarizes our current knowledge of pathophysiological mechanisms of septic acute kidney injury focusing on hemodynamic alterations, peritubular dysfunction, role of inflammatory mediators and nitric oxide, mitochondrial dysfunction and structural chan ges. Role of proteomics, new promising laboratory method, is mentioned.
Databáze:	Katalog Knihovny AV ČR
Externí odkaz:	Online Access