Electrocardiography in two models of isoproterenol-induced left ventricular remodeling.

Autor:	Kráľová, Eva
Další autoři:	Mokráň, T. Murín, Ján, 1949- Stankovičová, Tatiana
Jazyk:	angličtina
Předmět:	kardiovaskulární fyziologie elektrokardiografie potkan cardiovascular physiology electrocardiography Rattus norvegicus články journal articles isoproterenol ventricular remodeling
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: We studied the ability of the ECG to detect pathological changes in isoproterenol-induced remodeling of rat heart. Myocardial hypertrophy in rats was induced by repeated injections of isoproterenol (5 mg/kg s.c. 7 days, Iso5, n=7). Single overdose of isoproterenol (150 mg/kg s.c., Iso150, n=7) evoked myocardial infarction followed with ventricular remodeling. The electrocardiograms were recorded in anesthetized animals (thiopenthal 45 mg/kg i.p.) and myocardial contractile performance was analyzed in isolated hearts perfused according to Langendorff. The hypertrophic hearts were characterized by increased heart and left ventricular (LV) weight as well as by thicker LV free wall and interventricular septum. Mean values of LV contraction did not significantly differ from controls. Longer QT interval, QRS complex, negative Q and S waves, higher R amplitude were typical characteristics for Iso5 rats. Iso150 animals showed tendency to decreased systolic blood pressure and heart frequency. Decrease in the thickness of LV compared to Iso5 as well as impaired LV function were related to the dilated left ventricle. Iso150 ECG showed longer QRS and QT, deepened negativity of S wave and mild decrease of RII compared to Iso5. Voltage criteria showed that Sokolow-Lyon index is a good predictor of left ventricular hypertrophy in isoproterenol-induced cardiac remodeling without systemic hypertension.
Databáze:	Katalog Knihovny AV ČR
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