Intracelullar mediators in regulation of leptin secretion from adipocytes.

Autor:	Szkudelski, Tomasz
Jazyk:	angličtina
Předmět:	fyziologie leptin mastné kyseliny adenosin vápník physiology fatty acids adenosine calcium články journal articles adipocity mTOR adenosin trifostát (ATP) cyklický adenosinmonofosfát (cAMP) malonyl-CoA adipocytes mTOR (mammalian target of rapamycin) adenosine triphosphate (ATP) cyclic adenosine monophosphate (cAMP)
Druh dokumentu:	Non-fiction
ISSN:	0862-8408
Abstrakt:	Abstract: Leptin is a hormone primarily secreted by adipocytes and participating in the regulation of food intake and energy expenditure. Its blood levels usually correlate with adiposity. The secretion of this hormone is affected, among others, by food consumption, insulin, fasting and cold exposure. Regulation of leptin secretion depends on many intracellular events. It is known that the activation of mTOR (the mamma lian target of rapamycin) as well as increase in ATP and malonyl-CoA content in adipocytes enhance secretion of leptin. The rise in intracellular cAMP and fatty acids is thought to evoke the opposite effect. Moreover, the undisturbed action of endogenous adenosine in adipocytes and the proper intracellular Ca2+ concentration in these cells were also found to have an important function in leptin release. The role of mTOR, ATP, cAMP, fatty acids, malonyl-CoA, adenosine and Ca2+ in the regulation of leptin secretion from adipocytes is discussed.
Databáze:	Katalog Knihovny AV ČR
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