Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex.
Autor: | Kiyoshi, Masato1, Caaveiro, Jose M. M.2,3, Miura, Eri1, Nagatoishi, Satoru2, Nakakido, Makoto3, Soga, Shinji4, Shirai, Hiroki4, Kawabata, Shigeki4, Tsumoto, Kouhei1,2,3,5 tsumoto@bioeng.t.u-tokyo.ac.jp |
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Zdroj: | PLoS ONE. Jan2014, Vol. 9 Issue 1, p1-9. 9p. |
Databáze: | Academic Search Ultimate |
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