The novel anti-inflammatory agent VA694, endowed with both NO-releasing and COX2-selective inhibiting properties, exhibits NO-mediated positive effects on blood pressure, coronary flow and endothelium in an experimental model of hypertension and endothelial dysfunction.

Autor: Martelli, A.1, Testai, L.1, Anzini, M.2, Cappelli, A.2, Di Capua, A.2, Biava, M.3, Poce, G.3, Consalvi, S.3, Giordani, A.4, Caselli, G.4, Rovati, L.4, Ghelardini, C.5, Patrignani, P.6, Sautebin, L.7, Breschi, M.C.1, Calderone, V.1 calderone@farm.unipi.it
Zdroj: Pharmacological Research. Dec2013, Vol. 78, p1-9. 9p.
Databáze: Academic Search Ultimate