Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia.

Autor:	Christopher D. Cox1, Michael J. Breslin1, David B. Whitman1, John D. Schreier1, Georgia B. McGaughey1, Michael J. Bogusky1, Anthony J. Roecker1, Swati P. Mercer1, Rodney A. Bednar1, Wei Lemaire1, Joseph G. Bruno1, Duane R. Reiss1, C. Meacham Harrell1, Kathy L. Murphy1, Susan L. Garson1, Scott M. Doran1, Thomayant Prueksaritanont1, Wayne B. Anderson1, Cuyue Tang1, Shane Roller1
Zdroj:	Journal of Medicinal Chemistry. Jul2010, Vol. 53 Issue 14, p5320-5332. 13p.
Databáze:	Academic Search Ultimate
Externí odkaz:	Zobrazit plný text záznamu