Changes in γ-secretase activity and specificity caused by the introduction of consensus aspartyl protease active motif in Presenilin 1.

Autor: Carter, Donald B.1 donald@ameritech.net, Dunn, Edwige1 EDunn@net-link.net, Pauley, Adele M.2 adele.m.pauley@pfizer.com, McKinley, Denise D.1 MCKINLEY_DENISE_D@LILLY.COM, Fleck, Timothy J.1 timothy.j.fleck@pfizer.com, Ellerbrook, Brenda R.3 brenda.r.ellerbrock@pfizer.com, Stratman, Nancy C.3 nancy.c.stratman@pfizer.com, Xiangdong Zhou4 zhoux@ccf.org, Himes, Carol S.1 pooher@cs.com, Nye, Jeffrey S.1 jnye@prdus.jnj.com, Tomasselli, Alfredo2,5 alfredo.tomasselli@pfizer.com, Riqiang Yan1,4 yanr@ccf.org
Zdroj: Molecular Neurodegeneration. 2008, Vol. 3, Special section p1-12. 12p. 2 Black and White Photographs, 4 Charts, 3 Graphs.
Databáze: Academic Search Ultimate