Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective αvβ3 inhibitor: Design, synthesis, and optimization

Autor:	Nagarajan, Srinivasan R.1 Srinivasan.Nagarajan@Pfizer.com, Lu, Hwang-Fun1, Gasiecki, Alan F.2, Khanna, Ish K.2, Parikh, Mihir D.1, Desai, Bipinchandra N.2, Rogers, Thomas E.1, Clare, Michael2, Chen, Barbara B.2, Russell, Mark A.2, Keene, Jeffery L.1, Duffin, Tiffany1, Engleman, V. Wayne1, Finn, Mary B.1, Freeman, Sandra K.1, Klover, Jon A.1, Nickols, G. Alan1, Nickols, Maureen A.1, Shannon, Kristen E.1, Steininger, Christina A.1
Zdroj:	Bioorganic & Medicinal Chemistry. May2007, Vol. 15 Issue 10, p3390-3412. 23p.
Databáze:	Academic Search Ultimate
Externí odkaz:	Zobrazit plný text záznamu Full Text from ScienceDirect