The small inhibitor WM-1119 effectively targets KAT6A-rearranged AML, but not KMT2A-rearranged AML, despite shared KAT6 genetic dependency.

Autor: Sheridan, Mathew1 (AUTHOR), Maqbool, Muhammad Ahmad1,2 (AUTHOR), Largeot, Anne1,3 (AUTHOR), Clayfield, Liam1 (AUTHOR), Xu, Jingru1 (AUTHOR), Moncaut, Natalia4 (AUTHOR), Sellers, Robert5 (AUTHOR), Whittle, Jessica1 (AUTHOR), Paggetti, Jerome3 (AUTHOR), Iqbal, Mudassar6 (AUTHOR), Aucagne, Romain7 (AUTHOR), Delva, Laurent7 (AUTHOR), Baker, Syed Murtuza6 (AUTHOR), Lie-a-Ling, Michael1 (AUTHOR), Kouskoff, Valerie8 (AUTHOR), Lacaud, Georges1 (AUTHOR) georges.lacaud@cruk.manchester.ac.uk
Zdroj: Journal of Hematology & Oncology. 10/8/2024, Vol. 17 Issue 1, p1-18. 18p.
Databáze: Academic Search Ultimate
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