Synthetic lethality of combined ULK1 defection and p53 restoration induce pyroptosis by directly upregulating GSDME transcription and cleavage activation through ROS/NLRP3 signaling.

Autor: Chen, Wei1,2,3,4 (AUTHOR), Yang, Kai-Bin1,2 (AUTHOR), Zhang, Yuan-Zhe1,2 (AUTHOR), Lin, Zai-Shan1,2 (AUTHOR), Chen, Jin-Wei2 (AUTHOR), Qi, Si-Fan2 (AUTHOR), Wu, Chen-Fei1,2,4 (AUTHOR), Feng, Gong-Kan2 (AUTHOR), Yang, Da-Jun2 (AUTHOR) yangdj@sysucc.org.cn, Chen, Ming1,2 (AUTHOR) chenm326@mail.sysu.edu.cn, Zhu, Xiao-Feng2 (AUTHOR) zhuxfeng@mail.sysu.edu.cn, Li, Xuan1,2 (AUTHOR) lixuan56@mail.sysu.edu.cn
Zdroj: Journal of Experimental & Clinical Cancer Research (17569966). 8/31/2024, Vol. 43 Issue 1, p1-20. 20p.
Databáze: Academic Search Ultimate
Nepřihlášeným uživatelům se plný text nezobrazuje