Design, synthesis, anti-inflammatory evaluation, and molecular modelling of new coumarin-based analogs combined curcumin and other heterocycles as potential TNF-α production inhibitors via upregulating Nrf2/HO-1, downregulating AKT/mTOR signalling pathways and downregulating NF-κB in LPS induced macrophages

Autor: Ghany, Lina M. A. Abdel1 (AUTHOR), Beshay, Botros Y.2 (AUTHOR) Botros_beshay@aast.edu, Youssef Moustafa, Amal M.3 (AUTHOR), Maghrabi, Ali Hassan Ahmed4 (AUTHOR), Ali, Eman Hussain Khalifa5 (AUTHOR), Saleem, Rasha Mohammed6 (AUTHOR), Zaki, Islam7 (AUTHOR), Ryad, Noha8 (AUTHOR)
Zdroj: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2023, Vol. 38 Issue 1, p1-13. 13p.
Databáze: Academic Search Ultimate
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