A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
| Autor: | Chao Tu1, Terraube, Virginie2, Pui Tam, Amy Sze1, Stochaj, Wayne1, Fennell, Brian J.2, Laura Lin1, Stahl, Mark1, LaVallie, Edward R.1, Somers, Will1, Finlay, William J. J.2, Mosyak, Lydia1, Bard, Joel1 joel.bard@pfizer.com, Cunningham, Orla2 orla.cunningham@pfizer.com |
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| Zdroj: | Journal of Biological Chemistry. 1/15/2016, Vol. 291 Issue 3, p1267-1276. 10p. |
| Databáze: | Academic Search Ultimate |
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