Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study.

Autor: Braun, Joseph M.1 joseph_braun_1@brown.edu, Kalkbrenner, Amy E.2, Just, Allan C.3, Yolton, Kimberly4, Calafat, Antonia M.5, Sjödin, Andreas5, Hauser, Russ3, Webster, Glenys M.6,7, Chen, Aimin8, Lanphear, Bruce P.6,7
Předmět:
Zdroj: Environmental Health Perspectives. May2014, Vol. 122 Issue 5, p513-520. 8p. 2 Charts, 2 Graphs.
Abstrakt: Background: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult. Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors. Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a twostage hierarchical analysis to account for repeated measures and confounding by correlated EDCs. Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (≤ 1.5). Each 2‑SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE‑28) (β = 2.5; 95% CI: –0.6, 5.6) or trans-nonachlor (β = 4.1; 95% CI: 0.8–7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB‑178 (β = –3.0; 95% CI: –6.3, 0.2), β-hexachlorocyclohexane (β = –3.3; 95% CI: –6.1, –0.5), or PBDE‑85 (β = –3.2; 95% CI: –5.9, –0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (β = –2.0; 95% CI: –4.4, 0.4). Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, β‑hexachlorocyclohexane, PCB‑178, PBDE‑28, PBDE‑85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors. [ABSTRACT FROM AUTHOR]
Databáze: GreenFILE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje