Co-exposure of the organic nanomaterial fullerene C60 with benzo[a]pyrene in Danio rerio (zebrafish) hepatocytes: Evidence of toxicological interactions.

Autor:	Ferreira, Josencler L. Ribas1,2,3 josenclerf@gmail.com, Lonné, María Noelia4, França, Thiago A.1, Maximilla, Naiana R.1, Lugokenski, Thiago H.5, Costa, Patrícia G.6, Fillmann, Gilberto6, Antunes Soares, Félix A.5, de la Torre, Fernando R.7, Monserrat, José María1,2,3,8
Předmět:	Nanostructured materials Fullerenes Physiological effects of benzopyrene Zebra danio Liver cells Cell survival Toxicological interactions
Zdroj:	Aquatic Toxicology. Feb2014, Vol. 147, p76-83. 8p.
Abstrakt:	Highlights: [•] Fullerene C60 and PAH benzo[a]pyrene (BaP) synergistic effects were tested. [•] C60 increased cellular intake of BaP. [•] C60 decreased cell viability and phase II detoxificatory response triggered by BaP. [•] In silico, C60 molecule can inhibit the enzyme glutathione-S-transferase. [•] C60 can increase toxicity of PAHs possibly through delivery mechanisms. [Copyright &y& Elsevier]
Databáze:	GreenFILE
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