Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005-2010.

Autor:	Darrow, Lyndsey A.1 ldarrow@emory.edu, Stein, Cheryl R.2, Steenland, Kyle3
Předmět:	*Epidemiology *Fluorocarbons Confidence intervals Interviewing Evaluation of medical care Research funding Logistic regression analysis Data analysis Data analysis software Descriptive statistics Pregnancy
Zdroj:	Environmental Health Perspectives. Oct2013, Vol. 121 Issue 10, p1207-1213. 7p. 1 Diagram, 6 Charts.
Abstrakt:	Background: Previous research suggests perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) may be associated with adverse pregnancy outcomes. Objective: We conducted a population-based study of PFOA and PFOS and birth outcomes from 2005 through 2010 in a Mid-Ohio Valley community exposed to high levels of PFOA through drinking-water contamination. Methods: Women provided serum for PFOA and PFOS measurement in 2005-2006 and reported reproductive histories in subsequent follow-up interviews. Reported singleton live births among 1,330 women after 1 January 2005 were linked to birth records (n = 1,630) to identify the out­comes of preterm birth (< 37 weeks gestation), pregnancy-induced hypertension, low birth weight (< 2,500 g), and birth weight (grams) among full-term infants. Results: We observed little or no evidence of association between maternal serum PFOA or PFOS and preterm birth (n = 158) or low birth weight (n = 88). Serum PFOA and PFOS were both posi­tively associated with pregnancy-induced hypertension (n = 106), with adjusted odds ratios (ORs) per log unit increase in PFOA and PFOS of 1.27 (95% CI: 1.05, 1.55) and 1.47 (95% CI: 1.06, 2.04), respectively, but associations did not increase monotonically when categorized by quintiles. Results of subanalyses restricted to pregnancies conceived after blood collection were consistent with the main analyses. There was suggestion of a modest negative association between PFOS and birth weight in full-term infants (-29 g per log unit increase; 95% CI: -66, 7), which became stronger when restricted to births conceived after the blood sample collection (-49 g per log unit increase; 95% CI: -90, -8). Conclusion: Results provide some evidence of positive associations between measured serum per­fluorinated compounds and pregnancy-induced hypertension and a negative association between PFOS and birth weight among full-term infants. [ABSTRACT FROM AUTHOR]
Databáze:	GreenFILE
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