| Abstrakt: |
N-Nitrosodimethylamine (NDMA) has been assessed as a Priority Substance under the Canadian Environmental Protection Act. Based upon laboratory studies in which tumours have been induced in all species examined at relatively low doses, NDMA is clearly carcinogenic, with a very strong likelihood that the mode of action for the induction of tumours involves direct interaction with genetic material. Qualitatively, the metabolism of NDMA appears to be similar in humans and animals; as a result, it is considered highly likely that NDMA is carcinogenic to humans. A Tumorigenic Dose[sub 05] (TD[sub 05]) of 34 µg/kg body weight per day has been derived, based upon the benchmark dose associated with a 5% increase in the development of hepatic biliary cystadenomas in female rats in an oral carcinogenicity bioassay. [ABSTRACT FROM AUTHOR] |
