Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakstan: high levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in agricultural villages of southern Kazakstan

Autor: Stephens, Robert D., Hooper, Kim, Winkler, Jennifer, Visita, Pat, She, Jianwen, Sharmanov, Turgeldy, Hayward, Douglas, McKinney, Michael, Wade, Timothy J., Chuvakova, Tamara, Kazbekova, Gulnara, Petreas, Myrto X., Grassman, Jean, Druz, Natalia, Seminova, Gulnara
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Zdroj: Environmental Health Perspectives. Dec1998, Vol. 106 Issue 12, p797. 0p.
Abstrakt: To assess levels of chlorinated contaminants in breast milk, we measured organochlorine pesticides, polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) in breast milk samples collected in 1994 according to the WorldHealth Organization protocol from 92 donors that were representativeof regional populations in southern Kazakstan. High levels (10-120 pg/g fat) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic of the PCDD/PCDF congeners, were found in breast milk samples from an agricultural region. TCDD was the major contributor (75%) to the international toxicity equivalents of these samples. The same distinctive PCDD/PCDF congener pattern was found in 15 breast milk samples and 4 serum samples collected in 1996 in a follow-up study, and has nowbeen confirmed by three analytical laboratories. [ABSTRACT FROM AUTHOR]
Databáze: GreenFILE