| Autor: |
Farias, Paulina, Fishbein, Eugenia, Meneses-Gonzalez, Fernando, Palazuelos, Eduardo, Hernandez-Avila, Mauricio, Rubenstein, Elizabeth, Hu, Howard, Aro, Antonio |
| Předmět: |
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| Zdroj: |
Environmental Health Perspectives. Nov1998, Vol. 106 Issue 11, p733. 0p. |
| Abstrakt: |
Although lead has been extensively studied in children, its sources and effects remain unclear in adolescents. This study examined the relation of blood and tibia bone lead levels to lead determinants. One hundred adolescents living in Mexico City and surrounding suburbs were studied. Blood lead was measured by atomic absorption spectroscopy,and tibia lead was measured by a K X-ray Fluorescence (KXRF) instrument. Blood lead ranged from 1.8 to 29.2 micro g/dl, with a mean of 7.4 micro g/dl. Bone lead ranged from <1 to 44.82 micro g Pb/g bone mineral, with a mean of 4.8 micro g Pb/g. Predictors of bone lead included higher traffic density near the home, mother's smoking history, and time spent outdoors. Predictors of log-transformed blood lead included bone lead levels, male sex, use of lead-glazed ceramics, and living in Mexico City. Bone lead remained a significant predictor of blood lead after adjusting for covariates in a final multivariate regression model. In our final model, a rise in bone lead from the middle ofthe lowest quintile to the middle of the highest quintile (a difference of 21.6 micro g Pb/g) was associated with an increase in blood lead of 1.2 micro g/dl. Our data suggest that in addition to current sources of environmental lead exposure, bone lead accumulated over timeconstitutes a moderate source of circulating lead during adolescenceand may account for some of the adverse health effects documented inrecent studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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