| Autor: |
Salter, Mary A., Jameson, C. William, Law, Alistair J., Patison, Nicole, Mahaffey, Kathryn R., Gulson, Brian L., Korsch, Michael J., Mizon, Karen J. |
| Předmět: |
|
| Zdroj: |
Environmental Health Perspectives. Oct1998, Vol. 106 Issue 10, p667. 0p. |
| Abstrakt: |
We have obtained stable lead isotope and lead concentration data from a longitudinal study of mobilization of lead from the maternal skeleton during pregnancy and lactation and in which the newly born infants were monitored for 6 months postpartum to evaluate the effects of the local environment on lead body burden of the infant. Samples of maternal and infant blood, urine, and diet and especially breast milk were measured for 21 mothers and 24 infants. Blood lead concentrations were less than 5 5g/dl in all except one subject. The mean lead concentration in breast milk 1 standard deviation was 0.73 1 0.70 micro g/kg. In seven subjects for whom serial breast milk sampling was possible, the lead concentration varied by factors of from 2 to 4, and for three subjects there was an increase at or after 90 days postpartum. For the first 60-90 days postpartum, the contribution from breast milk to blood lead in the infants varied from36 to 80%. Multiple linear regression analyses indicated statistically significant relationships for some of the variables of isotope ratios and lead concentrations between breast milk, blood, urine, and diet for infants and mothers. For example, the analyses revealed that both a mother's breast milk 207 Pb/ 206 Pb and 206 Pb/ 204 Pb ratios and lead concentration provide information to predict her infant's blood 207 Pb/ 206 Pb and 206 Pb/ 204 Pb ratios. The major sources oflead in breast milk are from the maternal bone and diet. An evaluation of breast milk lead concentrations published over the last 15 years indicates that studies in which the ratio of lead concentrations inbreast milk to lead concentrations in whole maternal blood ( 100) were greater than 15 should be viewed with caution because of potentialcontamination during sampling and/or laboratory analyses. Selected studies also appear to show a linear relationship between breast milk and [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
|
