| Autor: |
Shepherd, Eric C.1, Phillips, Timothy D.1, Joiner, Gary N.1, Kubena, Leon F.2, Heidelbaugh, Norman D.1 |
| Zdroj: |
Journal of Environmental Science & Health. Part B. Pesticides, Food Contaminants & Agricultural Wastes. Jan1981, Vol. 16 Issue 5, p557-573. 17p. |
| Abstrakt: |
Penicillic Acid (PA) and Ochratoxin A (OA) are toxic fungal metabolites that are synergistic in combination. This interaction was investigated using mice which were dosed orally as follows: control, none; solvent control, 0.2 ml bicarbonate buffer; PA, 40 mg/kg; OA, 10 mg/kg and combination, 40 mg/kg PA + 10 mg/kg OA. The only significant histopathologic change observed was an acute multifocal toxic tubular nephrosis which appeared most severe in the combination‐treated mice killed on day 10. While the combination group had a death rate of 20% (5/25), no deaths occurred in the other treatment groups. The increased death rate and the extensive nephrotoxic findings in the combination group indicate a toxic interaction between OA and PA at sub‐lethal dose levels and is consistent with a renal site of action. [ABSTRACT FROM PUBLISHER] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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