| Abstrakt: |
Groups of 10 male and 10 female rats were fed α,α,α‐, α,2,6‐or 2,3,6‐trichlorotoluene (TCT) in their diet at 0, 0.5, 5.0, 50 or 500 ppm for 28 days. Growth rate and food consumption were not affected by treatment. No deaths occurred. Significant increases in liver weights were observed in male rats fed 5.0 and 500 ppm 2,3,6‐TCT. Mild serum biochemical changes occurred in male rats. These included increased SDH activities in the groups fed 5.0 and 50 ppm α,α,α‐TCT, and 5.0 ppm 2,3,6‐TCT. α,α,α‐TCT at 500 ppm caused elevated LDH activities in male rats. Hepatic microsomal aminopyrine N‐deroethylase activities were increased in male rats fed 500 ppm α,2,6‐TCT. Hematological parameters were not affected by treatment. Mild histological changes were seen in the liver, kidney and thyroid of treated rats. Data presented here suggest that α,α,α‐, α,2,6‐ and 2,3,6‐TCT possess a low order of oral toxicity in the rat. [ABSTRACT FROM PUBLISHER] |
