Effects of surfactants on the contents of metallothionein, heme and hemoproteins and on the activities of heme oxygenase and drug-metabolizing enzymes in rats pretreated with phenobarbital or β-naphthoflavone.

Autor:	Ariyoshi, Toshihiko1, Hasegawa, Hiroyuki1, Matsumoto, Hideki1, Arizono, Koji1
Předmět:	Physiological effects of surface active agents Heme Metallothionein Hemoproteins Heme oxygenase Laboratory rats Phenobarbital Liver analysis
Zdroj:	Bulletin of Environmental Contamination & Toxicology. Jan1991, Vol. 46 Issue 1, p120-127. 8p.
Abstrakt:	The article focuses on the study concerning the impacts of surfactants on contents of heme, metallothionein (MT), and hemoproteins and on the activities of heme oxygenase and drug-metabolizing enzymes in the rat liver pretreated with phenobarbital or ß-naphthoflavone (NF). The study used Male Wistar rats. It shows that several metabolites derived from Emulgen 913 may be responsible for the loss of cytochrome P-450 in the liver.
Databáze:	GreenFILE
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