| Autor: |
Hosgood III, H. Dean1 hosgoodd@mail.nih.gov, Boffetta, Paolo2,3,4, Greenland, Sander5, Yuan-Chin Amy Lee5, McLaughlin, John6, Seow, Adeline7, Duell, Eric J.8, Andrew, Angeline S.9, Zaridze, David10, Szeszenia-Dabrowska, Neonila11, Rudnai, Peterÿ12, Lissowska, Jolanta13, Fabinov, Eleon¢ra14, Mates, Dana15, Bencko, Vladimir16, Foretova, Lenka17, Janout, Vladimir18, Morgenstern, Hal19, Rothman, Nathaniel1, Hung, Rayjean J.6 |
| Předmět: |
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| Zdroj: |
Environmental Health Perspectives. Dec2010, Vol. 118 Issue 12, p1743-1747. 5p. |
| Abstrakt: |
Background: Domestic fuel combustion from cooking and heating is an important public health issue because roughly 3 billion people are exposed worldwide. Recently, the International Agency for Research on Cancer classified indoor emissions from household coal combustion as a human carcinogen (group 1) and from biomass fuel (primarily wood) as a probable human carcinogen (group 2A). Objectives: We pooled seven studies from the International Lung Cancer Consortium (5,105 cases and 6,535 controls) to provide further epidemiological evaluation of the association between in-home solid-fuel use, particularly wood, and lung cancer risk. Methods: Using questionnaire data, we classified subjects as predominant solid-fuel users (e.g., coal, wood) or nonsolid-fuel users (e.g., oil, gas, electricity). Unconditional logistic regression was used to estimate the odds ratios (ORs) and to compute 95% confidence intervals (CIs), adjusting for age, sex, education, smoking status, race/ethnicity, and study center. Results: Compared with nonsolid-fuel users, predominant coal users (OR = 1.64; 95% CI, 1.49-1.81), particularly coal users in Asia (OR = 4.93; 95% CI, 3.73-6.52), and predominant wood users in North American and European countries (OR = 1.21; 95% CI, 1.06-1.38) experienced higher risk of lung cancer. The results were similar in never-smoking women and other subgroups. Conclusions: Our results are consistent with previous observations pertaining to in-home coal use and lung cancer risk, support the hypothesis of a carcinogenic potential of in-home wood use, and point to the need for more detailed study of factors affecting these associations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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