| Autor: |
Ohura, Takeshi1 ooura@smail.u-shizuoka-ken.ac.jp, Kurihara, Ryo1, Hashimoto, Shinya1 |
| Předmět: |
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| Zdroj: |
Toxicological & Environmental Chemistry. Apr2010, Vol. 92 Issue 4, p737-742. 6p. 1 Diagram, 1 Chart. |
| Abstrakt: |
Hydroxylated polycyclic aromatic hydrocarbons (OH-PAH) with less than four rings are frequently found in the environment, whereas the toxicities associated with these compounds remain unclear. In this study, aryl hydrocarbon receptor (AhR)-ligand binding activities of OH-PAH were investigated by using a recombinant yeast assay system. The majority of the OH-PAH tested showed AhR-ligand binding activities, especially, when the hydroxylated derivatives of naphthalene were incubated with recombinant yeast. The structure-activity relationship between AhR activity and molecular weight or the octanol-water partition coefficient value of OH-PAH displayed significant correlations. These findings indicate that the site and number of hydroxy-groups substituted on PAH skeleton apparently influenced the AhR - ligand binding activity in the recombinant yeast assay. [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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