| Abstrakt: |
In some geographical areas human and animal populations are compelled to use salty water. In this study, tolerable and toxic salt concentrations were evaluated in rat, pig, and rabbit. Ninety Wistar rats weighing approximately 250 g were allocated to nine groups for study. For treatment, distilled water, 0.5, 1, 1.2, 1.4, 1.6, 1.8 or 2% salt (NaCl) concentrations were consumed by test groups, while the control group consumed Zanjan potable water. All animals were observed twice daily for mortality or evidence of morbidity. Serum sodium levels and plasma osmolarity were measured at the onset of experiment and 120 h later. Similar experimental conditions were employed in pig and rabbit. Rat tolerated 0.5, 1, and 1.2% NaCl concentrations in drinking water but higher concentrations were toxic and life threatening, accompanied by significantly increased serum sodium levels and plasma osmolarity. This study showed that pig was the most sensitive and rabbit the most resistant species to different NaCl concentrations. Although NaCl concentrations lower than 1.4% was considered as tolerable in rat, the animal health was affected. NaCl concentrations of 1.4% and higher may jeopardize animal health and were considered as toxic amounts. [ABSTRACT FROM AUTHOR] |
