| Autor: |
Chun S. Yu1, Feng T. Yeh1, Fu S. Yu2, Kwong C. Cheng3, Jing G. Chung4 jgchung@mail.cmu.edu.tw |
| Předmět: |
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| Zdroj: |
Toxicological & Environmental Chemistry. Jan-Mar2005, Vol. 87 Issue 1, p83-90. 8p. 2 Graphs. |
| Abstrakt: |
The present study was carried out to evaluate the question of whether or not royal jelly affects N-acetylation and metabolism of 2-aminofluorene (2-AF) in the human liver tumor cell line (J 5). N-acetylation and metabolism of 2-AF in intact J5 cells was determined by using high performance liquid chromatography for the amounts of acetylated and nonacetylated 2-AF and profile of 2-AF metabolism. The results indicated that royal jelly displayed a dose-dependent inhibition of N-acetylation of 2-AF in J5 cells. Royal jelly also decreased the profile of 2-AF metabolites in J5 cells. This report is the first demonstration which showed that royal jelly affects N-acetylation of 2-AF in human liver tumor cells (J5). [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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