| Autor: |
Cabagna, Mariana C.1, Lajmanovich, Rafael C.2 rafalajmanovich@yahoo.com.ar, Peltzer, Paola M.2, Attademo, Andrés M.2, Ale, Ezequiel3 |
| Předmět: |
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| Zdroj: |
Toxicological & Environmental Chemistry. Oct2006, Vol. 88 Issue 4, p729-737. 9p. 4 Black and White Photographs, 1 Graph. |
| Abstrakt: |
Cypermethrin (CY) is an active cyano pyrethroid effective against a wide range of pests encountered in agriculture and forestry. Although CY is not mutagenic in in vitro assays for gene mutation, in vivo assays showed conflicting results. In vivo genotoxicity of the synthetic pyrethroid CY in erythrocytes of Odontophrynus americanus tadpoles was examined. The frequency of micronuclei (MN) was recorded in blood smears obtained from tadpoles exposed in vivo to four different nominal concentrations 5, 10, 20 or 40 µg L-1 of the compound and fixed at two sampling times 48 and 96 h. As a positive control larvae were exposed to 40 mg L-1 of cyclophosphamide (CP). Tadpoles exposed to all CY treatments showed a significant increase in single small MN compared to the negative control group after 48 h and at 5 and 10 µg L-1 of CY at 96 h. Results obtained here demonstrated the genotoxic effects of the commercial formulation CY in the anuran larvae analyzed. Thus, data suggest that measurements of MN and other erythrocytes morphological aberrations performed in circulating blood samples of O. americanus tadpoles is a method for detecting cytogenetic damage in other native species. [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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