A Prospective Analysis of Per- and Polyfluoroalkyl Substances from Early Pregnancy to Delivery in the Atlanta African American Maternal-Child Cohort.
| Autor: | Youran Tan1 youran.tan@emory.edu, Eick, Stephanie M.1, Dunlop, Anne L.2, Barr, Dana Boyd1, Taibl, Kaitlin R.1, Steenland, Kyle1, Kannan, Kurunthachalam3, Robinson, Morgan3, Che-Jung Chang4, Panuwet, Parinya1, Yakimavets, Volha1, Marsit, Carmen J.1, Ryan, P. Barry1, Donghai Liang1 donghai.liang@emory.edu |
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| Předmět: |
*Fluorocarbons
African Americans T-test (Statistics) Data analysis Maternal exposure Research funding Socioeconomic factors Multiple regression analysis Pregnancy outcomes Multivariate analysis Descriptive statistics Maternal-fetal exchange Longitudinal method Gestational age Intraclass correlation Statistics Sulfur acids Confidence intervals Data analysis software Pregnancy |
| Zdroj: | Environmental Health Perspectives. Nov2024, Vol. 132 Issue 11, p117001-1-117001-15. 15p. |
| Abstrakt: | BACKGROUND: Longitudinal trends in per- and polyfluoroalkyl substances (PFAS) serum concentrations across pregnancy have not been thoroughly examined, despite evidence linking prenatal PFAS exposures with adverse birth outcomes. OBJECTIVES: We sought to characterize longitudinal PFAS concentrations across pregnancy and to examine the maternal–fetal transfer ratio among participants in a study of risk and protective factors for adverse birth outcomes among African Americans. METHODS: In the Atlanta African American Maternal–Child cohort (2014–2020), we quantified serum concentrations of four PFAS in 376 participants and an additional eight PFAS in a subset of 301 participants during early (8–14 weeks gestation) and late pregnancy (24–30 weeks gestation). Among these, PFAS concentrations were also measured among 199 newborns with available dried blood spot (DBS) samples. We characterized the patterns, variability, and associations in PFAS concentrations at different time points across pregnancy using intraclass correlation coefficients (ICCs), maternal–newborn pairs transfer ratios, linear mixed effect models, and multivariable linear regression, adjusting for socioeconomic and prenatal predictors. RESULTS: Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were detected in >95% of maternal samples, with PFHxS and PFOS having the highest median concentrations. We observed high variability in PFAS concentrations across pregnancy time points (ICC=0.03–0.59). All median PFAS concentrations increased from early to late pregnancy, except for PFOA and N-methyl perfluorooctane sulfonamido acetic acid (NMFOSAA), which decreased [paired 푡-test for all PFAS 푝<0.05 except for PFOA and perfluorobutane sulfonic acid (PFBS)]. Prenatal serum PFAS were weakly to moderately correlated with newborn DBS PFAS (-0.05 |
| Databáze: | GreenFILE |
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