Evaluating the Effect of Gestational Exposure to Perfluorohexane Sulfonate on Placental Development in Mice Combining Alternative Splicing and Gene Expression Analyses.

Autor:	Yihao Zhang1,2, Jia Lv1,2, Yi-Jun Fan1,2,3, Lin Tao1,2, Jingjing Xu1,2, Weitian Tang1,2, Nan Sun1,2, Ling-Li Zhao1,2, De-Xiang Xu1,2,4 xudex@126.com, Yichao Huang1,2,4 yichao.huang@ahmu.edu.cn
Předmět:	*Biomarkers *Pollutants *Animal experimentation *Amides Amino acid analysis Maternal exposure Reverse transcriptase polymerase chain reaction Body weight Metabolomics Fetal development Fetal growth retardation Metabolism Placenta Gene expression profiling Histological techniques Multiomics Messenger RNA Cell proliferation Mice Phenotypes Pregnancy
Zdroj:	Environmental Health Perspectives. Nov2023, Vol. 131 Issue 11, p117011-1-117011-16. 16p.
Abstrakt:	The article discusses research which aimed to investigate the gestational exposure of mice to human-relevant doses of perfluorohexane sulfonate (PFHxS). Cited are the integrity and quantity of messenger RNA (mRNA) that are essential in placental function and fetal development which was measured using a combination of alternative splicing and genome-wide expression analyses, and epidemiological findings regarding the associations of PFHxS with lower birth weight.
Databáze:	GreenFILE
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