| Autor: |
Chen, Dan1 (AUTHOR), Lou, Xinyu1 (AUTHOR), Bao, Junsong2 (AUTHOR), Wang, Ying1,3 (AUTHOR), Fan, Yuhao1 (AUTHOR), Chen, Qianhui1 (AUTHOR), Jin, Jun1,3 (AUTHOR) junjin3799@126.com, Chen, Limei1,4,5 (AUTHOR) chenlimei919@163.com |
| Předmět: |
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| Zdroj: |
Environmental Research. Sep2023, Vol. 232, pN.PAG-N.PAG. 1p. |
| Abstrakt: |
Polychlorinated naphthalenes (PCNs) have stopped being produced and used but have been detected in human serum around the world. Investigating temporal trends in PCN concentrations in human serum will improve our understanding of human exposure to PCNs and the risks posed. We determined the PCN concentrations in serum collected from 32 adults in five consecutive years (2012–2016). The total PCN concentrations in the serum samples were 0.00–5443 pg/g lipid weight. We found no significant decreases in the total PCN concentrations in human serum and even found that the concentrations of some PCN congeners (e.g., CN20) increased over time. We found differences in the PCN concentrations in serum from males and females, the CN75 concentration being significantly higher in serum from females than males, meaning CN75 poses more serious risks to females than males. We found, using molecular docking techniques, that CN75 interferes with thyroid hormone transport in vivo and that CN20 affects thyroid hormone binding to receptors. These two effects are synergistic and can cause hypothyroidism-like symptoms. [Display omitted] • No significant decreases in the total PCN concentrations in human serum from 2012 to 2016. • CN20 was the dominant congener and its concentrations increased over time. • Higher concentrations of CN75 in serum samples from female than male. • CN20 and CN75 may disrupt the binding of thyroid hormone to TRβ1 and TBG respectively. [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
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