| Autor: |
Yan, Xiangjuan1,2 (AUTHOR), Zhao, Fei1,2 (AUTHOR), Wang, Guosheng1,2 (AUTHOR), Wang, Zhen1,2 (AUTHOR), Zhou, Mingxi3 (AUTHOR), Zhang, Limin1,4 (AUTHOR), Wang, Guoxiang1,2 (AUTHOR), Chen, Yanshan1,2 (AUTHOR) chenyanshan@njnu.edu.cn |
| Zdroj: |
Bulletin of Environmental Contamination & Toxicology. Jan2023, Vol. 110 Issue 1, p1-6. 6p. |
| Abstrakt: |
The widespread occurrence of cyanobacteria blooms damages the water ecosystem and threatens the safety of potable water and human health. Exogenous L-lysine significantly inhibits the growth of a dominant cyanobacteria Microcystis aeruginosa in freshwater. However, the molecular mechanism of how lysine inhibits the growth of M. aeruginosa is unclear. In this study, both non-target and target metabolomic analysis were performed to investigate the effects of algicide L-lysine. The results showed that 8 mg L− 1 lysine most likely disrupts the metabolism of amino acids, especially the arginine and proline metabolism. According to targeted amino acid metabolomics analysis, only 3 amino acids (L-arginine, ornithine, and citrulline), which belong to the ornithine-ammonia cycle (OAC) in arginine metabolic pathway, showed elevated levels. The intracellular concentrations of ornithine, citrulline, and arginine increased by 115%, 124%, and 19.4%, respectively. These results indicate that L-lysine may affect arginine metabolism and OAC to inhibit the growth of M. aeruginosa. [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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