Toxicity of Mixtures of Polychlorinated Dibenzo-p-dioxins, Dibenzofurans, and Biphenyls Determined by Dose-Response Curve Analysis.

Autor:	Li, W.1, Wu, W. Z.1,2, Schramm, K.-W.2, Xu, Y.1, Kettrup, A.2
Předmět:	*Tetrachlorodibenzodioxin *Polychlorinated dibenzodioxins *Dioxins *Aromatic compounds *Environmental toxicology *Pollutants *Environmental health *Toxicology Toxic polyhalogenated aromatic hydrocarbon
Zdroj:	Bulletin of Environmental Contamination & Toxicology. May99, Vol. 62 Issue 5, p539-546. 8p. 4 Charts, 4 Graphs.
Abstrakt:	The article discusses the result of the study which aims to evaluate the combined effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) with five polyhalogenated aromatic hydrocarbons which are all considered as environmental pollutants that bioaccumulate throughout the food chain and pose health risk to humans and animals. A dose-response curve (DRC) analysis reveals that ethoxyresorufin-O-deethylase activity of TCDD, tetrachlorodibenzofuran, octachlorodibenzodioxins, polychlorinated biphenyls(PCB)126, PCB77, and PCB153 were dose-dependent. Researchers states that this non-additive response can be an important consideration in the development of a toxic equivalent factor approach for hazard and risk assessment.
Databáze:	GreenFILE
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