Autor: |
Lee, Younghyun1 (AUTHOR), Kang, Jin-Kyu1,2,3 (AUTHOR), Lee, Yang Hee1 (AUTHOR), Yoon, Hyo Jin1 (AUTHOR), Yang, Su San1 (AUTHOR), Kim, Seung Hyun1 (AUTHOR), Jang, Seongjae1 (AUTHOR), Park, Sunhoo4,5 (AUTHOR), Heo, Da Hye4 (AUTHOR), Jang, Won Il4,6 (AUTHOR), Yoo, Hyung Jun4,6 (AUTHOR), Paik, Eun Kyung4,6 (AUTHOR), Lee, Hyo Rak1,4,7 (AUTHOR) cisplatin@kirams.re.kr, Seong, Ki Moon1 (AUTHOR) skmhanul@kirams.re.kr |
Předmět: |
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Zdroj: |
Mutation Research - Genetic Toxicology & Environmental Mutagenesis. Dec2021, Vol. 872, pN.PAG-N.PAG. 1p. |
Abstrakt: |
• Chromosome aberrations increase during partial-body and fractionated radiotherapy. • Heightened levels of chromosome aberrations persisted throughout 1-year follow-up. • Cytogenetic biomarkers reflected partial-body radiation exposure more than 1 year. Although radiological accidents often result in partial-body radiation exposure, most biodosimetry studies focus on estimating whole-body exposure doses. We have evaluated time-dependent changes in chromosomal aberrations before, during, and after localized fractionated radiotherapy. Twelve patients with carcinoma in situ of the breast who underwent identical adjuvant radiation therapy (50 Gy in 25 fractions) were included in the study. Lymphocytes were collected from patients before, during, and after radiotherapy, to measure chromosome aberrations, such as dicentric chromosomes and translocations. Chromosome aberrations were then used to calculate whole- and partial-body biological absorbed doses of radiation. Dicentric chromosome frequencies in all study participants increased during radiotherapy (p < 0.05 in Kruskal-Wallis test). Increases of translocation frequencies during radiotherapy were observed in seven of the twelve patients. The increased levels of dicentric chromosomes and translocations persisted throughout our 1-year follow-up, and evidence of partial-body exposure (such as Papworth's U-value > 1.96) was observed more than 1 year after radiotherapy. We found that cytogenetic biomarkers reflected partial-body fractionated radiation exposure more than 1 year post-exposure. Our findings suggest that chromosome aberrations can be used to estimate biological absorbed radiation doses and can inform medical intervention for individuals suspected of fractionated or partial-body radiation exposure. [ABSTRACT FROM AUTHOR] |
Databáze: |
GreenFILE |
Externí odkaz: |
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