Personal Exposure to Black Carbon at School and Levels of Fractional Exhaled Nitric Oxide in New York City.

Autor:	Kyung Hwa Jung¹, Goodwin, Kathleen E.¹, Perzanowski, Matthew S.², Chillrud, Steven N.³, Perera, Frederica P.², Miller, Rachel L.⁴, Lovinsky-Desir, Stephanie¹ sl3230@cumc.columbia.edu
Předmět:	Air pollution Carbon *Environmental exposure Research Confidence intervals Inflammation Multivariate analysis Regression analysis Mathematical variables Schools Respiration Data analysis software
Zdroj:	Environmental Health Perspectives. Sep2021, Vol. 129 Issue 9, p1-097005-10. 10p. 2 Diagrams, 2 Charts, 4 Graphs.
Abstrakt:	BACKGROUND: Schools are often located near traffic sources, leading to high levels of exposure to traffic-related air pollutants, including black carbon (BC). Thus, the school environment could play in a significant role in the adverse respiratory health of children. OBJECTIVES: Our objective was to determine associations between personal BC levels at school and airway inflammation [i.e., fractional exhaled nitric oxide (FeNO)] in school-age children. We hypothesized that higher school BC (SBC) would be associated with higher FeNO. METHODS: Children 9-14 years of age in New York City (NYC) (푛=114) wore BC monitors for two 24-h periods over a 6-d sampling period, repeated 6 months later. SBC was defined as the average personal BC concentrations measured during NYC school hours (i.e., 0830-1430 hours). FeNO was measured following each 24-h BC monitoring period. Multivariable linear regression in generalized estimating equation models were used to examine associations between SBC and FeNO. Results are presented as percentage difference (PD) in FeNO. RESULTS: Personal BC at school was associated with higher FeNO (PD=7.47% higher FeNO per 1-μ g/m³ BC (95% CI: 1.31, 13.9), 푝=0.02]. Compared with BC exposure during school, a smaller PD in FeNO was observed in association with BC exposure while commuting to and from school [PD=6.82% (95% CI: 0.70, 13.3), 푝=0.03]. Personal BC in non-school environments and residential BC were not associated with FeNO (푝>0.05). A significant association between personal BC at school and FeNO was observed among children with seroatopy who did not have asthma [PD=21.5% (95% CI: 4.81, 40.9), 푝=0.01]. DISCUSSION: Schools may be important sources of BC exposure that contribute to airway inflammation in school-age children. Our results provide rationale for interventions that target improved air quality in urban schools and classrooms. [ABSTRACT FROM AUTHOR]
Databáze:	GreenFILE
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