Improved Rapid Analytical Method for the Urinary Determination of 3,5,6 Trichloro-2-Pyridinol, a Metabolite of Chlorpyrifos.

Autor:	MacKenzie, B. A.1, Striley, C. A. F.1, Biagini, R. E.1, Stettler, L. E.1, Hines, C. J.2
Předmět:	*Biochemistry *Pesticides *Toxins Metabolites Effect of xenobiotics on microorganisms Plant metabolites Biomolecules Xenobiotics
Zdroj:	Bulletin of Environmental Contamination & Toxicology. Jul2000, Vol. 65 Issue 1, p1-7. 7p.
Abstrakt:	The article discusses the improved rapid analytical method for the urinary determination of 3,5,6 trichloro-2-pyridinol, a metabolite of chiorpyrifos. Urinary immunoassays have been used as screens for occupational exposure to a variety of compounds, including pesticides Immunoassays are generally quite sensitive, specific and accurate. However, biotransformation of xenobiotics may lead to urinary excretion of metabolites, which, in some cases, may lead to modulation of immunoreactivity yielding an over/under estimation of apparent body burdens, presumably from enhanced/inhibited competition by metabolic conjugates.
Databáze:	GreenFILE
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