Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children.
| Autor: | Gade Timmermann, Clara Amalie1 atimmermann@health.sdu.dk, Jensen, Kristoffer Jarlov2,3, Nielsen, Flemming1, Budtz-Jørgensen, Esben4, van der Klis, Fiona5, Stabell Benn, Christine2,6, Grandjean, Philippe1,7, Fisker, Ane Bærent2,6,8 |
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| Předmět: |
*Diseases
*Fluorocarbons *Pollutants *Environmental exposure Measles prevention Confidence intervals Immunoglobulins Measles vaccines Mothers Regression analysis Research funding Viral antibodies Logistic regression analysis Descriptive statistics Middle-income countries Low-income countries Antibody formation Odds ratio Mann Whitney U Test Maternal exposure Kruskal-Wallis Test Children |
| Zdroj: | Environmental Health Perspectives. Aug2020, Vol. 128 Issue 8, p087002-1-087002-11. 11p. 2 Diagrams, 4 Charts. |
| Abstrakt: | BACKGROUND: Perfluoroalkyl substances (PFAS) are a group of widely used persistent chemicals with suspected immunotoxic effects. OBJECTIVES: The present study aimed to examine the association between infant PFAS exposure and antibody responses to measles vaccination as well as morbidity in a low-income country. METHODS: In a randomized controlled trial, children from Guinea-Bissau, West Africa, were followed from inclusion (4–7 months of age) through 2 years of age. Half the children received two measles vaccinations (at inclusion and at 9 months of age), and the other half received only one (at 9 months of age). In a subset of 237 children, six PFAS were quantified in serum at inclusion, and measles antibody concentrations were assessed at inclusion and at approximately 9 months and 2 years of age. At inclusion and at the 9-month visit, mothers were interviewed about infant morbidity. RESULTS: All but one child had detectable serum concentrations of all six PFAS, although levels were lower than seen elsewhere. A doubling in perfluorooctane sulfonic acid (PFOS) and perfluorodecanoic acid (PFDA) were associated with 21% (95% CI: 2, 37%) and 25% (95% CI: 1, 43%), respectively, lower measles antibody concentrations at the 9-month visit among the children who had received a measles vaccine at inclusion. Elevated serum PFAS concentrations were also associated with reduced prevaccination measles antibody concentrations and increased morbidity. DISCUSSION: The present study documents that PFAS exposure has reached West Africa and that infants show PFAS-associated increases in morbidity and decreases in measles-specific antibody concentrations before and after vaccination. These findings support the evidence on PFAS immunotoxicity at comparatively low serum concentrations. [ABSTRACT FROM AUTHOR] |
| Databáze: | GreenFILE |
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