A Protocol to Select High Quality Datasets of Ecotoxicity Values for Pesticides.

Autor: Roncaglioni, Alessandra1 (AUTHOR), Benfenati, Emilio1 (AUTHOR) benfenati@marionegri.it, Boriani, Elena1 (AUTHOR), Clook, Mark2 (AUTHOR)
Předmět:
Zdroj: Journal of Environmental Science & Health. Part B. Pesticides, Food Contaminants & Agricultural Wastes. Jul2004, Vol. 39 Issue 4, p641-652. 12p.
Abstrakt: The key to any QSAR model is the underlying dataset. In order to construct a reliable dataset to develop a QSAR model for pesticide toxicity, we have derived a protocol to critically evaluate the quality of the underlying data. In developing an appropriate protocol that would enable data to be selected in constructing a QSAR, we concentrated on one toxicity end point, the 96 h LC50 from the acute rainbow trout study. This end point is key in pesticide regulation carried out under 91/414/EEC. The dataset used for this exercise was from the US EPA-OPP database. [ABSTRACT FROM AUTHOR]
Databáze: GreenFILE
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