Gestational Exposures to Phthalates and Folic Acid, and Autistic Traits in Canadian Children.
| Autor: | Oulhote, Youssef1,2 youlhote@umass.edu, Lanphear, Bruce3, Braun, Joseph M.4, Webster, Glenys M.3, Arbuckle, Tye E.5, Etzel, Taylor4, Forget-Dubois, Nadine2, Seguin, Jean R.6, Bouchard, Maryse F.7, MacFarlane, Amanda8, Ouellet, Emmanuel2, Fraser, William9, Muckle, Gina2 |
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| Předmět: |
*Plasticizers
*Environmental exposure Autism risk factors Confidence intervals Dietary supplements Folic acid Neuropsychological tests Metabolites First trimester of pregnancy Research funding Risk assessment Sex distribution Urinalysis Logistic regression analysis Social disabilities Behavior disorders Descriptive statistics Prenatal exposure delayed effects |
| Zdroj: | Environmental Health Perspectives. Feb2020, Vol. 128 Issue 2, p027004-1-027004-12. 12p. 3 Charts, 3 Graphs. |
| Abstrakt: | BACKGROUND: The etiology of autism spectrum disorder is poorly understood. Few studies have investigated the link between endocrine-disrupting chemicals and autistic traits. We examined the relationship between gestational phthalates and autistic traits in 3- to 4-y-old Canadian children. We also investigated potential effect modification by sex and folic acid supplementation. METHODS: We enrolled 2,001 women >18 years of age during the first trimester of pregnancy between 2008 and 2011 from 10 cities in Canada. At 3–4 years of age, 610 children underwent neuropsychological assessments including the Social Responsiveness Scale–II (SRS-2) as a measure of autistic traits and social impairment. We measured 11 phthalate metabolites in maternal first trimester urine samples and assessed folic acid supplementation from reported intakes. We estimated covariate-adjusted differences in SRS-2 푇-scores with a doubling in phthalate concentrations in 510 children with complete data. RESULTS: Mean total SRS 푇-score was 45.3 (SD = 6.1). Children with higher gestational exposure to mono-n-butyl (MBP) and mono-3- carboxypropyl (MCPP) concentrations exhibited significantly higher total SRS 푇-scores, indicating greater overall social impairment, as well as higher scores on subdomains, indicating deficits in social cognition, social communication, social motivation, and restricted interests/repetitive behaviors. A doubling in MBP or MCPP concentrations was associated with 0.6 (95% CI: 0.1, 1.0) and 0.5 (95% CI: 0.1, 0.8) higher total SRS 푇-scores. Associations were consistently and significantly stronger in boys (ßMBP = 1.0; 95% CI: 0.4, 1.6; n = 252) compared with girls (ßMBP = 0.1; 95% CI: -0.6, 0.7; n = 258) and among children who had lower prenatal folic acid supplementation (<400 µg/d) (bMBP = 1:3; 95% CI: 0.4, 2.3; n = 59) compared with those who had adequate folic acid supplementation (=400 µg/d) (ßMBP = 0:4; 95% CI: -0:1, 0.8; n = 451). CONCLUSIONS: Higher gestational concentrations of some phthalate metabolites were associated with higher scores of autistic traits as measured by the SRS-2 in boys, but not girls; these small size effects were mitigated by first trimester-of-pregnancy folic acid supplementation. [ABSTRACT FROM AUTHOR] |
| Databáze: | GreenFILE |
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