Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study.

Autor: Havet, Anaïs1,2 (AUTHOR) anais.havet@gmail.com, Li, Zhen3 (AUTHOR) lizhenscu@163.com, Zerimech, Farid4 (AUTHOR) farid.zerimech@chru-lille.fr, Sanchez, Margaux5 (AUTHOR) margaux.sanchez@anses.fr, Siroux, Valérie6 (AUTHOR) valerie.siroux@univ-grenoble-alpes.fr, Le Moual, Nicole1,2 (AUTHOR) nicole.lemoual@inserm.fr, Brunekreef, Bert7,8 (AUTHOR) b.brunekreef@uu.nl, Künzli, Nino9,10 (AUTHOR) nino.kuenzli@unibas.ch, Jacquemin, Bénédicte1,2 (AUTHOR) benedicte.jacquemin@inserm.fr, Varraso, Raphaëlle1,2 (AUTHOR) raphaelle.varraso@inserm.fr, Matran, Régis11 (AUTHOR) regis.matran@univ-lille.fr, Nadif, Rachel1,2 (AUTHOR) rachel.nadif@inserm.fr
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Zdroj: Environmental Health: A Global Access Science Source. 10/29/2019, Vol. 18 Issue 1, pN.PAG-N.PAG. 1p. 1 Diagram, 3 Charts.
Abstrakt: Background: Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma.Methods: Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM10) and ≤ 2.5 μm were estimated by ESCAPE models (2009-2010), and ozone (O3) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution.Results: FlOPs levels increased with PM10 and O3 (adjusted β = 0.04 (95%CI 0.001-0.08), aβ = 0.04 (95%CI 0.009-0.07) per 10 μg/m3, respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08-3.02)). The risk of persistent asthma decreased with exposures to NO2, NOx and PM2.5 (aOR ranging from 0.62 to 0.94), and increased with exposures to PM10, O3, O3-summer and road traffic, the greater effect being observed for O3 (aOR = 1.78, 95% CI 0.73-4.37, per 10 μg/m3). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70-11.9), a positive direct effect of O3 on persistent asthma (OR = 1.68, 95%CI 0.57-7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01-2.29)) accounting for 41% of the total effect.Conclusions: Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma. [ABSTRACT FROM AUTHOR]
Databáze: GreenFILE
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