Polyunsaturated fatty acids and child neurodevelopment among a population exposed to DDT: a cohort study.

Autor: Mérida-Ortega, Ángel1 angel.merida@espm.insp.mx, Rothenberg, Stephen J.1 rothenberg@insp.mx, Torres-Sánchez, Luisa1 ltorress@insp.mx, Schnaas, Lourdes2 lschnaas@hotmail.com, Hernández-Alcaraz, César1 cesar.hernandez@espm.insp.mx, Cebrián, Mariano E.3 mcebrian@cinvestav.mx, García-Hernández, Rosa María3 rmgarcia@cinvestav.mx, Ogaz-González, Rafael1 rafaogaz@hotmail.com, López-Carrillo, Lizbeth1 lizbeth@insp.mx
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Zdroj: Environmental Health: A Global Access Science Source. 2/28/2019, Vol. 18 Issue 1, pN.PAG-N.PAG. 1p. 1 Diagram, 4 Charts.
Abstrakt: Background: Child neurodevelopment has been positively linked to maternal intake of polyunsaturated fatty acids (PUFAs) during pregnancy; however, it is unknown if that relationship persists among populations exposed to environmental neurotoxicants.Objective: The aim of this work was to assess whether maternal dietary intake of PUFAs during pregnancy is positively associated with child neurodevelopment, whose mothers were environmentally exposed to 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT).Methods: A prospective cohort study with 276 mother-child pairs was performed in Mexico. Neurodevelopment was assessed by Bayley Scales II from children age 1 to 30 months. Dietary PUFAs intake was estimated by Food Frequency Questionnaire at 1st and 3rd trimester of pregnancy. DDE (1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene, the main metabolite of DDT) maternal serum levels were determined by electron capture gas chromatography. Longitudinal multivariate linear mixed-effects analysis, which combines mental (MDI) and motor (PDI) Bayley scales in a single model, were performed.Results: Our results show that in a sample environmentally exposed to DDT, maternal ingestion of DPA during the first trimester of pregnancy was positively associated with MDI (β = 0.10, 95% CI 0.02, 0.18) in children from 1 to 30 months. Likewise, our results suggest that dietary ALA may be also related to MDI.Conclusion: DPA may benefit neurodevelopment even in populations exposed to DDT. Our results strengthen the importance of PUFAs intake during the prenatal period. [ABSTRACT FROM AUTHOR]
Databáze: GreenFILE
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