High Pesticide Exposure Events and Olfactory Impairment among U.S. Farmers.
| Autor: | Shrestha, Srishti1, Kamel, Freya1, Umbach, David M.2, Freeman, Laura E. Beane3, Koutros, Stella3, Alavanja, Michael3, Blair, Aaron3, Sandler, Dale P.1, Honglei Chen1,4 hchen@epi.msu.edu |
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| Předmět: |
*Agricultural laborers
*Agriculture *Herbicides *Insecticides *Pesticides *Environmental exposure Smell disorders Confidence intervals Hand washing Longitudinal method Research funding Self-evaluation Logistic regression analysis Occupational hazards Data analysis software Odds ratio Disease risk factors |
| Zdroj: | Environmental Health Perspectives. Jan2019, Vol. 127 Issue 1, p1-9. 9p. 4 Charts. |
| Abstrakt: | BACKGROUND: Olfactory impairment (OI) is common among older adults and independently predicts all-cause mortality and the risk of several major neurodegenerative diseases. Pesticide exposure may impair olfaction, but empirical evidence is lacking. OBJECTIVE: We aimed to examine high pesticide exposure events (HPEEs) in relation to self-reported OI in participants in the Agricultural Health Study (AHS). METHODS: We conducted multivariable logistic regression to examine the associations between HPEEs reported at enrollment (1993-1997) and self-reported OI at the latest AHS follow-up (2013-2015) among 11,232 farmers, using farmers without HPEEs as the reference or unexposed group. RESULTS: A total of 1,186 (10.6%) farmers reported OI. A history of HPEEs reported at enrollment was associated with a higher likelihood of reporting OI two decades later {odds ratio ðORÞ=1:49 [95% confidence interval (CI): 1.28, 1.73]}. In the analyses on the HPEE involving the highest exposure, the association appears to be stronger when there was a >4-h delay between HPEE and washing with soap and water [e.g., OR=2:07 (95% CI: 1.48, 2.89) for 4-6 h vs. OR=1:39 (95% CI: 1.11, 1.75) for <30 min]. Further, significant associations were observed both for HPEEs involving the respiratory or digestive tract [OR=1:53 (95% CI: 1.22, 1.92)] and dermal contact [OR=1:47 (95% CI: 1.22, 1.78)]. Finally, we found significant associations with several specific pesticides involved in the highest exposed HPEEs, including two organochlorine insecticides (DDT and lindane) and four herbicides (alachlor, metolachlor, 2,4-D, and pendimethalin). HPEEs that occurred after enrollment were also associated with OI development. CONCLUSIONS: HPEEs may cause long-lasting olfactory deficit. Future studies should confirm these findings with objectively assessed OI and also investigate potential mechanisms. [ABSTRACT FROM AUTHOR] |
| Databáze: | GreenFILE |
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