Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years.
Autor: | Philippat, Claire1 claire.philippat@inserm.fr, Nakiwala, Dorothy1, Calafat, Antonia M.2, Botton, Jérémie3,4,5, De Agostini, Maria3,4, Heude, Barbara3,4, Slama, Rémy1 |
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Předmět: |
*Biomarkers
*Phenols *Pollutants *Environmental exposure Behavior disorders in children Confidence intervals Longitudinal method Probability theory Questionnaires Regression analysis Research funding Statistics Data analysis Data analysis software Descriptive statistics Intraclass correlation Pregnancy |
Zdroj: | Environmental Health Perspectives. Sep2017, Vol. 125 Issue 9, p1-9. 9p. 5 Charts. |
Abstrakt: | BACKGROUND: Sex-specific associations have been reported between phthalates, bisphenol A (BPA), and child behavior. No data on large study populations are available for other phenols with possible endocrine-disrupting properties. OBJECTIVES: We aimed to study associations between prenatal exposure to phthalates and several phenols on behavior among male infants. METHODS: We quantified 11 phthalate metabolites and nine phenols (four parabens, benzophenone-3, BPA, two dichlorophenols, triclosan) in spot urine samples collected during pregnancy among EDEN cohort mothers who delivered a boy. Mothers completed the Strength and Difficulties Questionnaire (SDQ) when their children were 3.1 (n=529) and 5.6 (n=464) y old. RESULTS: BPA was positively associated with the relationship problems subscale at 3 y [incidence rate ratio (IRR): 1.11; 95% confidence interval (CI): 1.03, 1.20] and the hyperactivity-inattention subscale scores at 5 y (IRR: 1.08; 95% CI: 1.01, 1.14). Mono-n-butyl phthalate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotional symptom scores at 3 y. Monobenzyl phthalate (MBzP) was positively associated with internalizing behavior and relationship problems scores at 3 y. After dichotomizing SDQ scores, triclosan tended to be positively associated with emotional symptom subscales at both 3 and 5 y. CONCLUSIONS: The observed associations between BPA, MnBP, and behavior in boys are consistent with previous findings. Further health impact assessment studies based on dose-response functions corrected for exposure misclassification are required to quantify the public health burden possibly entailed by such associations. [ABSTRACT FROM AUTHOR] |
Databáze: | GreenFILE |
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