Stress-Induced Transcriptional Changes and DNA Damage Associated with Bis(2-ethylhexyl) Adipate Exposure in Zebrafish ( Danio rerio) Larvae.

Autor: Boran, Halis1 halisboran@gmail.com, Terzi, Serap1
Předmět:
Zdroj: Bulletin of Environmental Contamination & Toxicology. Sep2017, Vol. 99 Issue 3, p308-314. 7p. 2 Color Photographs, 2 Charts, 3 Graphs.
Abstrakt: The present study evaluates potential toxic effects of bis(2-ethylhexyl) adipate (DEHA) plasticizer to larval (72 h post fertilization) zebrafish ( Danio rerio) by analyzing changes in expression levels of stress-related genes ( p53, rad51 and xrcc5) and assessing possible DNA damage of DEHA in larvae. The lethal concentration for 50% mortality (LC) in larval zebrafish exposed for 96 h to 0-200 mg L DEHA was 89.9 ± 8.03 mg L. A concentration-dependent increase in DNA strand breaks was detected in cells from larvae exposed for 96 h to DEHA. There were some significant differences in induction of stress-related genes in larvae exposed to DEHA relative to control. [ABSTRACT FROM AUTHOR]
Databáze: GreenFILE