Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study.

Autor:	Chao-Bin Liu¹, Xin-Ru Hong^2,3,4,5 chenxq63@yahoo.com.cn, Miao Shi^2,3, Xiao-Qiu Chen⁶, Hui-Juan Huang^2,3,4, Jin-Hua Chen⁷, Kai Yang⁴, Su-Qing Chen¹, Han-Qiang Chen⁸, Hai-Dong Kan⁹, Qing-Hua Sun¹⁰
Předmět:	Air pollution Particulate matter Congenital heart disease Cardiovascular system abnormalities Confidence intervals Research funding Logistic regression analysis Control groups Retrospective studies Case-control method Data analysis software Descriptive statistics Prenatal exposure delayed effects Odds ratio Disease risk factors Cardiovascular diseases risk factors
Zdroj:	Environmental Health Perspectives. May2017, Vol. 125 Issue 5, p1-8. 8p. 2 Charts, 1 Graph, 1 Map.
Abstrakt:	BACKGROUND: Maternal exposure to ambient air pollution has been associated with an increased risk of congenital heart defects in offspring; however, the results are inconsistent. OBJECTIVES: We investigated whether there is an association between prenatal exposure to particulate matter with diameter ≤10μm (PM10) during early pregnancy and fetal cardiovascular malformations. METHODS: The gravidae from a hospital-based case-control study in Fuzhou, China, during 2007-2013 were assigned 10-d or 1-mo averages of daily PM10 using an air monitor-based inverse distance weighting method during early pregnancy. A total of 662 live-birth or selectively terminated cases and 3,972 live-birth controls were enrolled. The exposure was considered as a categorical variable. A multivariable logistic regression model was constructed to quantify the adjusted odds ratios (aORs) of the exposure to PM10 and the risks of fetal cardiovascular malformations. RESULTS: PM10 levels were positively associated with the risks of atrial septal defect (aORs ranging from 1.29 to 2.17), patent ductus arteriosus [aORs = 1:54, 1.63; 95% confidence intervals (CIs): 1.17, 2.23; 1.06, 3.24], overall fetal cardiovascular malformations (aOR = 1:28; 95% CI: 1.03, 1.61), ventricular septal defect (aOR = 1:19; 95% CI: 1.00, 1.43), and tetralogy of Fallot (aOR = 1:44; 95% CI: 1.01, 2.19) in the various observed periods scaled by 10 d or 1 mo in the first and second gestation months. The strongest associations were observed for exposure to PM10 in the second quartile, whereas the associations were attenuated when higher concentrations of PM10 in the third and fourth quartiles of the exposure were evaluated. No correlations of PM10 levels with these cardiovascular malformations in the other time periods of gestation were observed. CONCLUSIONS: Our findings suggest some positive associations between maternal exposure to ambient PM10 during the first two months of pregnancy and fetal cardiovascular malformations. [ABSTRACT FROM AUTHOR]
Databáze:	GreenFILE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.