Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies.

Autor:	Raqib, Rubhana¹ rubhana@icddrb.org, Ahmed, Sultan^1,2, Bin Ahsan, Khalid¹, Kippler, Maria², Akhtar, Evana¹, Roy, Anjan Kumar, Ying Lu, 1², El Arifeen, Shams³, Wagatsuma, Yukiko⁴, Vahter, Marie²
Předmět:	Arsenic Immunity *Immunization Immunoglobulin analysis Anthropometry C-reactive protein Confidence intervals Immunoassay Immunoglobulins Longitudinal method Probability theory Regression analysis Research funding Rural conditions Sex distribution Statistics T-test (Statistics) Data analysis Multiple regression analysis MMR vaccines Data analysis software Descriptive statistics Mann Whitney U Test Kruskal-Wallis Test Children Pregnancy
Zdroj:	Environmental Health Perspectives. Jun2017, Vol. 125 Issue 6, p1-9. 9p. 4 Charts, 2 Graphs.
Abstrakt:	BACKGROUND: Early-life arsenic exposure has been associated with reduced cell-mediated immunity, but little is known about its effects on humoral immunity. OBJECTIVE: We evaluated whether prenatal and childhood arsenic exposure was associated with humoral immune function in school-aged children. METHODS: Children born in a prospective mother–child cohort in rural Bangladesh were immunized with measles, mumps, and rubella (MMR) vaccines at 9 years of age (n=525). Arsenic exposure was assessed in urine (U-As), from mothers during pregnancy and their children at 4.5 and 9 years of age. Total IgG (tIgG), tIgE, tIgA, and MMR-specific IgG concentrations were measured in plasma using immunoassays. RESULTS: Arsenic exposure was positively associated with child tIgG and tIgE, but not tIgA. The association with tIgG was mainly apparent in boys (p for interaction=0.055), in whom each doubling of maternal U-As was related to an increase in tIgG by 28 mg/dL. The associations of U-As at 9 years with tIgG and tIgE were evident in underweight children (p for interaction <0.032). Childhood arsenic exposure tended to impair mumps-specific vaccine response, although the evaluation was complicated by high preimmunization titers. Postimmunization mumps–specific IgG titers tended to decrease with increasing U-As at 4.5 and 9 years of age [regression coefficient (β)=-0.16; 95% confidence interval (CI): -0.33, 0.01; p=0.064 and β=-0.12; 95% CI: -0.27, -0.029; p=0.113, respectively) in 25% children with the lowest preexisting mumps-specific IgG titers. CONCLUSIONS: Arsenic exposure increased tIgG and tIgE in plasma, and tended to decrease mumps-specific IgG in children at 9 years of age. [ABSTRACT FROM AUTHOR]
Databáze:	GreenFILE
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