Cloning and functional characterization of a retinoid X receptor orthologue in Platynereis dumerilii: An evolutionary and toxicological perspective.

Autor:	André, Ana1,2 iandre@ciimar.up.pt, Ruivo, Raquel1 rruivo@ciimar.up.pt, Capitão, Ana1,3, Froufe, Elsa1 efroufe@ciimar.up.pt, Páscoa, Inês1, Costa Castro, Luís Filipe1,3 filipe.castro@ciimar.up.pt, Santos, Miguel Machado1,3 santos@ciimar.up.pt
Předmět:	*Organotin compounds *Toxicology Retinoid X receptors Platynereis dumerilii Genetic transcription Cloning
Zdroj:	Chemosphere. Sep2017, Vol. 182, p753-761. 9p.
Abstrakt:	In the present work we provide the first isolation and functional characterization of a RXR orthologue in an annelid species, the Platynereis dumerilii . Using an in vitro luciferase reporter assay we evaluated the annelid receptor ability to respond to ligand 9- cis -retinoic acid, TBT and TPT. Our results show that the annelid RXR responds to 9- cis -retinoic acid and to the organotins by activating reporter gene transcription. The findings suggest a conserved mode of action of the receptor in response to a common signaling molecule and modulation by organotin compounds between vertebrates and Lophotrochozoans. [ABSTRACT FROM AUTHOR]
Databáze:	GreenFILE
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