| Autor: |
Rivero-Wendt, Carla Letícia Gediel1,2 leticiagediel@gmail.com, Oliveira, Rhaul2 rhaul.oliveira@gmail.com, Monteiro, Marta Sofia3 mmonteiro@ua.pt, Domingues, Inês3 inesd@ua.pt, Soares, Amadeu Mortágua Velho Maia3,4 asoares@ua.pt, Grisolia, Cesar Koppe2 grisolia@unb.br |
| Předmět: |
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| Zdroj: |
Environmental Toxicology & Pharmacology. Jun2016, Vol. 44, p107-113. 7p. |
| Abstrakt: |
The synthetic androgen 17α-methyltestosterone is widely used in fish aquaculture for sex reversion of female individuals. Little is known about the amount of MT residues reaching the aquatic environment and further impacts in non-target organisms, including fish early-life stages. Thus, in this work, zebrafish embryos were exposed to two forms of 17α-methyltestosterone: the pure compound (MT) and a formulation commonly used in Brazil (cMT). For MT, a 96 h-LC 50 of 10.09 mg/l was calculated. MT also affected embryo development inducing tail malformations, edemas, abnormal development of the head, and hatching delay. At biochemical level MT inhibited vitellogenin (VTG) and inhibited cholinesterase and lactate dehydrogenase. cMT elicited similar patterns of toxicity as the pure compound (MT). Effects reported in this study suggest a potential environmental risk of MT, especially since the VTG effects occurred at environmental relevant concentrations (0.004 mg/l). [ABSTRACT FROM AUTHOR] |
| Databáze: |
GreenFILE |
| Externí odkaz: |
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Full Text from ScienceDirect