Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Wen CC"'
Autor:
Kathleen M. Giacomini, Wen Cc, Mark N. Kvale, Thomas J. Hoffmann, Cathy Schaefer, Sook Wah Yee, Eric Jorgenson, Neil Risch, Xiaomin Liang, Yambazi Banda
Publikováno v:
Clinical Pharmacology & Therapeutics. 97:518-525
The first-line treatment of hyperuricemia, which causes gout, is allopurinol. The allopurinol response is highly variable, with many users failing to achieve target serum uric acid (SUA) levels. No genome-wide association study (GWAS) has examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec48e2a1f11be04df47c6c2d5c88129
https://doi.org/10.1002/cpt.89
https://doi.org/10.1002/cpt.89
Autor:
Dan M. Roden, Joel Mefford, Radojka M. Savic, Wen Cc, Sook Wah Yee, Kathleen M. Giacomini, Srijib Goswami, Sophie L. Stocker, Monique M. Hedderson, Jonathan D. Mosley, Claire M. Brett, John S. Witte, Robert L. Davis, Xiaomin Liang, Richard A. Castro, M. D. Simpson, Michiaki Kubo, Shiro Maeda
Publikováno v:
Clinical pharmacology and therapeutics, vol 96, iss 3
One-third of type 2 diabetes patients do not respond to metformin. Genetic variants in metformin transporters have been extensively studied as a likely contributor to this high failure rate. Here, we investigate, for the first time, the effect of gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37f3cd60f46b0f5cfb32c4542c11233
https://doi.org/10.1038/clpt.2014.109
https://doi.org/10.1038/clpt.2014.109
Autor:
Lu Xu, Doug Stryke, Eugene C. Chen, Xin Chen, Kathleen M. Giacomini, Jeff Simko, Sook Wah Yee, Susan J. Johns, Kacyn Fujii, Joseph F. Costello, Emil U. Almof, Wen Cc, Thomas E. Ferrin, Chibo Hong, Ligong Chen
Publikováno v:
The pharmacogenomics journal
Human organic cation transporter 3 (OCT3 and SLC22A3) mediates the uptake of many important endogenous amines and basic drugs in a variety of tissues. OCT3 is identified as one of the important risk loci for prostate cancer, and is markedly underexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ff6a2f9aa1da3dd20f480848f3d929
https://doi.org/10.1038/tpj.2011.60
https://doi.org/10.1038/tpj.2011.60
Autor:
Sook Wah Yee, Peter Skewes-Cox, Nadav Ahituv, Stephanie Hesselson, Hisayo Fukushima, Loan Nguyen, Jasmin L Eshragh, Susan J. Johns, Mee J. Kim, Laura B. Ramsey, Kathleen M. Giacomini, Thomas E. Ferrin, Mary V. Relling, Deanna L. Kroetz, Douglas Stryke, Pui-Yan Kwok, Richard A. Castro, Wen Cc
Publikováno v:
Clinical Pharmacology & Therapeutics. 89:571-578
Little is known about how genetic variations in enhancers influence drug response. In this study, we investigated whether nucleotide variations in enhancers that regulate drug transporters can alter their expression levels. Using comparative genomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31effd3cc703a9168001a9504ea2606a
https://doi.org/10.1038/clpt.2010.353
https://doi.org/10.1038/clpt.2010.353
Autor:
Wen, CC, Yee, SW, Liang, X, Hoffmann, TJ, Kvale, MN, Banda, Y, Jorgenson, E, Schaefer, C, Risch, N, Giacomini, KM
Publikováno v:
Clinical pharmacology and therapeutics, vol 97, iss 5
The first-line treatment of hyperuricemia, which causes gout, is allopurinol. The allopurinol response is highly variable, with many users failing to achieve target serum uric acid (SUA) levels. No genome-wide association study (GWAS) has examined th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::351f0b2640f5080f6bbededa56c4fcab
https://escholarship.org/uc/item/7r50w6p6
https://escholarship.org/uc/item/7r50w6p6
Publikováno v:
Cancer gene therapy. 18(12)
Human epidermal growth factor receptor 2 (HER2) is frequently overexpressed in human ovarian cancers and its overexpression is associated with increased angiogenesis, increased metastasis and reduced survival. Inhibition of HER2 in HER2-overexpressin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29d775a0f607a3fa073e483b54e8d14
https://pubmed.ncbi.nlm.nih.gov/21869825
https://pubmed.ncbi.nlm.nih.gov/21869825
Publikováno v:
Clinical pharmacology and therapeutics, vol 92, iss 5
Drug transporters play a key role in the absorption, distribution, and elimination of many drugs, and they appear to be important determinants of therapeutic and adverse drug activities. Although a large body of data pertaining to drug transporters i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47968a1754ce1cd4316223da7e35ca77
https://doi.org/10.1038/clpt.2012.44
https://doi.org/10.1038/clpt.2012.44
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