The effect of lung stretch during sleep on respiratory mechanics and variability in asthma
| Autor: | Campana, Lisa M. |
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| Rok vydání: | 2012 |
| Druh dokumentu: | Thesis/Dissertation |
| Popis: | Thesis (Ph.D.)--Boston University PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. Both obesity and sleep are two conditions which reduce lung volume and limit deep breaths. A lack of lung stretch may alter airway smooth muscle leading to bronchoconstriction in asthma. We hypothesize that inducing dynamic changes in lung volume during sleep would reduce airway resistance in asthma. Furthermore, we hypothesized those with asthma would have increased variability of resistance during sleep as compared to healthy controls, possibly leading to nocturnal arousals. Overweight and obese subjects were studied during sleep on two nights, one baseline and one with bi-level positive airway pressure (BPAP) applied through a nasal mask. Forced oscillations were used to measure respiratory system resistance (Rrs ) and reactance (Xrs ) throughout the night and epiglottic pressure was used to separate upper airway from lower airway resistance (Rup, Rlow). Ten controls and 10 asthma subjects were studied. Rrs, Rup, and Rlow, are larger (p 2031-01-01 |
| Databáze: | Networked Digital Library of Theses & Dissertations |
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